学术报告－生命科技学院

报告题目：1．Inhibitors of Cyclin-Dependent Kinases (Cdks) as Anticancer Therapeutics2．Development of Multi-Component Reactions (MCRs) for Combinatorial Parallel Synthesis3．Application of Yeast Three Hybrid Technology for Protein Target Identification报 告 人： Jianxing Huang（黄建星）, Ph.D.，Waltham, Massachusetts, USA 报告时间：2008年1月4日（星期五）下午3:00报告地点：新教学大楼A103　　　　　　　　附黄建星教授简介 欢迎广大师生踊跃参加！                                             生科院化学系                                           2008年1月2日  
黄建星教授简介：
2002-2007，Principal Scientist, Medicinal Chemistry, GPC-Biotech, Inc., Waltham, Massachusetts
• Structure based design and synthesis of inhibitors against protein kinases such as Cdks, Bcr-Abl, Src, and Raf, mutation and / or overexpression of which frequently lead to tumorigenesis.
• Identification of protein targets for small organic molecules using yeast three hybrid technologies.
1996-2002，Senior Scientist, Combinatorial Chemistry, ArQule, Inc., Woburn, Massachusetts
• Combinatorial library design; and assessment of library proposals based on their synthetic feasibility and drug-likeness.
• Combinatorial library synthesis using high through-put solution phase parallel synthesis.
1995-1996，Postdoctoral Research, Organic Chemistry, Harvard University, Cambridge, Massachusetts
• Design and synthesis of novel nucleoside analogs for the ribose ring conformation studies using NMR and X-ray crystallographic techniques.
1990-1995，Graduate Research, Organic Chemistry, Indiana University, Bloomington, Indiana
• Synthesis of oligonucleosides with phosphodiester linkages replaced by sulfonate or sulfonamide linkages, in order to map charge-charge interactions of DNA polymerases with their substrates.
• Sulfonate anion chemistry; preparation of naturally occurring small molecules (glycosides, phospholipids, nucleosides, and steroids) that were sulfonate incorporated.
1988-1990，Graduate Research, Biochemistry, University of San Francisco, San Francisco, California
• Purification of Dipeptidylaminopeptidase III from Dictyostelium discoideum, and enzyme specificity studies using the preparation.
1986-1988，Teaching Assistant, Department of Chemistry, Tongji University, Shanghai, P.R. China
• Research and development of polymeric thin film as condenser material with high dielectric constant and low dielectric dissipation properties. 
 
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