医学院学术讲座（十二）

  
 
题 目：Establishing the segmented body plan: Mechanisms controlling somitogenesis during embryonic development
主讲人：Dr. Miguel Maroto
              Welcome Trust Institute, University of Dundee, 英国
主持人：王华东教授   医学院副院长 
时   间：2010年10月21日（星期四）下午3:00
地   点：医学院五楼学术报告厅
 
Dr. Miguel Maroto简介：
Dr. Miguel Maroto毕业于西班牙马德里，在马德里获得博士学位后分别在国际上非常著名的胚胎发育segmentation clock研究Prof. Andrew B. Lassar 和Dr. Olivier Pourquie实验室工作。然后作为独立的PI在美国和英国（Welcome Trust Institute, University of Dundee）继续从事体节发生的基因调控的研究。Dr. Miguel Maroto在胚胎体节发生的基因调控研究领域国际上享有极高的声誉，有多篇文章发表在Nature, Cell, Developmental Cell, Gene and Development, Journal of Cell Biology等。
欢迎各位师生踊跃参加！
 
暨南大学医学院科研与研究生管理办公室
                                 2010年10月15日


Miguel Maroto’s selected publication
 
1. Maroto M, Arredondo JJ, San Roman M, Marco R, Cervera M (1995). Analysis of the paramyosin/miniparamyosin gene complex: Miniparamyosin is an independently transcribed, distinct paramyosin isoform, widely distributed in invertebrates. J. Biol. Chem. 270:4375-4382
2. Maroto M, Arredondo JJ, Goulding D, Marco R, Bullard B, Cervera M (1996). Drosophila paramyosin/miniparamyosin gene products show a large diversity in quantity, localization, and isoform pattern: a possible role in muscle maturation and function. J. Cell Biol. 134:81-92
3. Maroto M, Reshef R, Munsterberg A, Koester S, Goulding M, Lassar AB (1997). Ectopic Pax-3 activates MyoD and Myf-5 expresssion in embryonic mesoderm and neural tissue. Cell 89:139-148
4. Reshef R, Maroto M, Lassar AB (1998). Regulation of dorsal somitic cell fates: BMPs and noggin control the timing and pattern of myogenic regulator expression. Genes Dev. 12:290-303
5. Maroto M, Pourquie O (2001). A molecular clock involved in somite segmentation. Curr Top Dev Biol. Vol. 51:221-248
6. Dale JK*, Maroto M*, DequeantML, MalapertP, McGrew M, PourquieO (2003). Periodic Notch inhibition by Lunatic Fringe underlies the chick Segmentation Clock. Nature421:275-278
7. Dale JK, Malapert P, Chal J, Vilhais-Neto G, Maroto M, Johson T, Jayasinghe S, Trainor P, Herrmann B, Pourquie O (2006). Oscillations of the Snail genes in the presomitic mesoderm coordinate segmental patterning and morphogenesis in vertebrate somitogenesis. Dev. Cell 10:355-366
8. Ferjentsik Z, Hayashi S, Dale JK, Bessho Y, Herreman A, De Strooper B, del Monte G, de la Pompa JL, Maroto M (2009). Notch is a critical component of the mouse somitogenesis oscillator and is essential for the formation of the somites. PLoS Genetics 5(9):e1000662
9. Wright D, FerjentsikZ, Qiu X, Jiang YJ, Van Hateren N, Wilson SA, Malapert P, Pourquie O, Dale JK, Maroto M (2009). Cyclic Nrarp mRNA expression is regulated by the somitic oscillator but Nrarp protein levels do not oscillate. Dev Dyn 238:3043-3055
10. Tenin G, Wright D, Ferjentsik Z, Bone R, McGrew MJ, MarotoM (2010). The chick somitogenesis oscillator is arrested before all paraxial mesoderm is segmented into somites. BMC Dev Biol 10:24
11. Gibb S, Maroto M, Dale JK (2010). Segmentation clock comprehension moves up a Notch. Trends Cell Biol, Aug 17. [Epub ahead of print] doi:10.1016/j.tcb.2010.07.001 （http://dx.doi.org/10.1016/j.tcb.2010.07.001 ）
 
报告背景简介：脊椎动物 （http://baike.baidu.com/view/17224.htm ）在胚胎 （http://baike.baidu.com/view/32848.htm ）发育的过程中沿身体前后轴形成一定数目的暂时性结构——体节（somite），随着胚胎的继续发育每个体节分化成为生骨节，生皮节和生肌节，继而生成各种组织。而体节（somite）的形成（somitogenesis）是一个非常复杂的基因调控下具有时空性的发育过程。
 

作者：吉念宁